Prkn^tm1Rpa
Targeted Allele Detail

Summary

• Symbol: Prkn^tm1Rpa
• Name: parkin RBR E3 ubiquitin protein ligase; targeted mutation 1, Richard D Palmiter
• MGI ID: MGI:3055212
• Gene: Prkn Location: Chr17:11059271-12282248 bp, + strand Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
• Alliance: Prkn^tm1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95204
• Parent Cell Line: AK18.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Approximately 4 kb of the genomic sequence containing exon 2 were replaced with a construct containing the neo^r gene, driven by the polymerase (RNA) II (DNA directed) polypeptide A gene promoter, and the negative selection markers HSV-TK and PGK-DTA. (J:95204)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkn Mutation: 54 strains or lines available

References

• Original: J:95204 Perez FA, et al., Parkin-deficient mice are not a robust model of parkinsonism. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2174-9
• All: 3 reference(s)