Psmb8^tm1Hjf
Targeted Allele Detail

Summary

• Symbol: Psmb8^tm1Hjf
• Name: proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); targeted mutation 1, H J Fehling
• MGI ID: MGI:3055222
• Synonyms: beta5i^-, LMP-7^-, LMP7-
• Gene: Psmb8 Location: Chr17:34417169-34420428 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Psmb8^tm1Hjf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20012
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-5, encoding the first 247 amino acids of the protein, were replaced with a neomycin resistance gene. (J:20012)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Psmb8 Mutation: 15 strains or lines available

References

• Original: J:20012 Fehling HJ, et al., MHC class I expression in mice lacking the proteasome subunit LMP-7. Science. 1994 Aug 26;265(5176):1234-7
• All: 71 reference(s)