Dmbx1^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Dmbx1^tm1Bhr
• Name: diencephalon/mesencephalon homeobox 1; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:3055282
• Synonyms: Dmbx1^-
• Gene: Dmbx1 Location: Chr4:115772316-115797123 bp, - strand Genetic Position: Chr4, 53.07 cM
• Alliance: Dmbx1^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92785
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Floxed exons 2 and 3, encoding the homeodomain, introduced by homologous recombination were subsequently excised following Cre mediated recombination in the male germ line. Targeting took place in ES cells homozygous for the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells. (J:92785)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmbx1 Mutation: 20 strains or lines available

References

• Original: J:92785 Ohtoshi A, et al., Neonatal lethality, dwarfism, and abnormal brain development in Dmbx1 mutant mice. Mol Cell Biol. 2004 Sep;24(17):7548-58
• All: 1 reference(s)