Dmbx1^tm2Bhr
Targeted Allele Detail

Summary

• Symbol: Dmbx1^tm2Bhr
• Name: diencephalon/mesencephalon homeobox 1; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:3055285
• Synonyms: Dmbx1^z
• Gene: Dmbx1 Location: Chr4:115772316-115797123 bp, - strand Genetic Position: Chr4, 53.07 cM
• Alliance: Dmbx1^tm2Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92785
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-lacZ cassette with a floxed neomycin resistance cassette was inserted into intron 1. Expression of the mutated allele recapitulated the endogenous expression pattern. (J:92785)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmbx1 Mutation: 20 strains or lines available

References

• Original: J:92785 Ohtoshi A, et al., Neonatal lethality, dwarfism, and abnormal brain development in Dmbx1 mutant mice. Mol Cell Biol. 2004 Sep;24(17):7548-58
• All: 1 reference(s)