Sobp^jc-2J
Spontaneous Allele Detail

Summary

• Symbol: Sobp^jc-2J
• Name: sine oculis binding protein; Jackson circler 2 Jackson
• MGI ID: MGI:3055292
• Gene: Sobp Location: Chr10:42878496-43050526 bp, - strand Genetic Position: Chr10, 22.89 cM
• Alliance: Sobp^jc-2J page

Mutation origin

• Strain of Origin: B6.129S2-Il6^tm1Kopf/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This spontaneous mutation, discovered in a production colony at The Jackson Laboratory, was shown to be allelic with the original Jackson circler mutation by failure of the two alleles to complement one another. A G-to-T transversion occurs at coding nucleotide position 1894 (c.1894G>T) that converts the glycine codon at amino acid residue 632 to a stop codon (p.G632*). The resulting protein is reduced in length by 28%. (J:113021, J:137716)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sobp Mutation: 40 strains or lines available

References

• Original: J:113021 Calderon A, et al., Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res. 2006 Nov;221(1-2):44-58
• All: 2 reference(s)