Cd83^lcd4
Chemically induced Allele Detail

Summary

• Symbol: Cd83^lcd4
• Name: CD83 antigen; low CD4 cell
• MGI ID: MGI:3055293
• Synonyms: CD83mu, LCD4.1
• Gene: Cd83 Location: Chr13:43938661-43956608 bp, + strand Genetic Position: Chr13, 21.6 cM, cytoband A4-5
• Alliance: Cd83^lcd4 page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: The last exon contains a missense mutation that changes the stop codon to an arginine, extending the protein by 55 amino acids. Immunohistochemistry was unable to detect protein expression and Western blot revealed a severe reduction in the amount of protein. (J:92721)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd83 Mutation: 17 strains or lines available

References

• Original: J:92721 Garcia-Martinez LF, et al., A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol. 2004 Sep 1;173(5):2995-3001
• All: 3 reference(s)