Tekt2^{Gt(OST12401)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Tekt2^{Gt(OST12401)Lex}
• Name: tektin 2; gene trap OST12401, Lexicon Genetics
• MGI ID: MGI:3055308
• Synonyms: Tekt2^{Gt(Betageo)1Htan}
• Gene: Tekt2 Location: Chr4:126215914-126219481 bp, - strand Genetic Position: Chr4, 60.37 cM
• Alliance: Tekt2^{Gt(OST12401)Lex} page

Mutation origin

• Mutant Cell Line: OST12401
• Germline Transmission: Earliest citation of germline transmission: J:92779
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap containing a 5'-LTR, splice acceptor, betageo-pA, PGK-puro, splice donor, and a 3'-LTR was inserted into intron 9. Transcript was not detected in mutant testes in Northern blot analysis. Western blot confirmed lack of protein in testicular lysates of mutants. (J:92779)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST12401	CG480479 ; (MGI Seq Detail)	3' RACE	Chr4:126215925-126216212 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tekt2 Mutation: 37 strains or lines available

References

• Original: J:92779 Tanaka H, et al., Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. Mol Cell Biol. 2004 Sep;24(18):7958-64
• All: 2 reference(s)