Del(11Stat5a-Stat5b)1Mam
Targeted Allele Detail

Summary

• Symbol: Del(11Stat5a-Stat5b)1Mam
• Name: deletion, chr 11, Lothar Hennighausen 1
• MGI ID: MGI:3055320
• Synonyms: Stat5^-, Stat5ab^null, Stat5a/Stat5b^tm2.1Mam
• Gene: Del(11Stat5a-Stat5b)1Mam Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92770
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(11Stat5a-Stat5b)1Mam involves 2 genes/genome features (Stat5b, Stat5a) View all
• Mutation details: Cre-mediated recombination between Stat5a^tm2Mam and Stat5b^tm1Mam to remove both genes. (J:92770)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Stat5a-Stat5b)1Mam Mutation: 0 strains or lines available

References

• Original: J:92770 Cui Y, et al., Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004 Sep;24(18):8037-47
• All: 34 reference(s)