Tg(CD8aCD8b)57Scr
Transgene Detail

Summary

• Symbol: Tg(CD8aCD8b)57Scr
• Name: transgene insertion 57, The Scripps Research Institute
• MGI ID: MGI:3055355
• Transgene: Tg(CD8aCD8b)57Scr Location: unknown
• Alliance: Tg(CD8aCD8b)57Scr page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD8aCD8b)57Scr expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD8A (925)

  Cd8a	(MGI:88346)

  human

  CD8B (926)

  Cd8b1

  (MGI:88347)

• Mutation details: The transgene contains the human CD8 alpha and beta chain genes driven by the T cell-specific Lck promoter. CD8alpha-alpha homodimers were expressed on 62% of thymocytes and CD8alpha-beta heterodimers on 14% of thymocytes. Peripheral T cells preferentially expressed the CD8alpha-beta heterodimers at a 4:1 ratio. Human CD8alpha was detected on both CD4⁺ and CD8⁺ T cells. (J:92994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92994 LaFace DM, et al., Human CD8 transgene regulation of HLA recognition by murine T cells. J Exp Med. 1995 Nov 1;182(5):1315-25
• All: 2 reference(s)