Sh2b1^tm1Lr
Targeted Allele Detail

Summary

• Symbol: Sh2b1^tm1Lr
• Name: SH2B adaptor protein 1; targeted mutation 1, Liangyou Rui
• MGI ID: MGI:3055487
• Synonyms: SH2-B^-
• Gene: Sh2b1 Location: Chr7:126066166-126074596 bp, - strand Genetic Position: Chr7, 69.06 cM
• Alliance: Sh2b1^tm1Lr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92794
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter region through the majority of the coding sequence was replaced with a neomycin resistance gene. All isoforms are predicted to be eliminated and immunoblot confirmed that no wild-type protein was present in mutant livers. (J:92794)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sh2b1 Mutation: 49 strains or lines available

References

• Original: J:92794 Duan C, et al., Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol. 2004 Sep;24(17):7435-43
• All: 14 reference(s)