Nrg2^tm1Bus
Targeted Allele Detail

Summary

• Symbol: Nrg2^tm1Bus
• Name: neuregulin 2; targeted mutation 1, Samantha J Busfield
• MGI ID: MGI:3055488
• Synonyms: NRG-2
• Gene: Nrg2 Location: Chr18:36150705-36330433 bp, - strand Genetic Position: Chr18, 19.38 cM
• Alliance: Nrg2^tm1Bus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92972
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 2-4 of the gene. The deleted region encodes the immunoglobulin domain and most of the epidermal growth factor-like domain. RT-PCR analysis on adult cerebellum and cortex/hippocampus showed no detectable transcript. (J:92972)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg2 Mutation: 33 strains or lines available

Notes

ES cell line derived from 129X1/SvJ.

References

• Original: J:92972 Britto JM, et al., Generation and characterization of neuregulin-2-deficient mice. Mol Cell Biol. 2004 Sep;24(18):8221-6
• All: 1 reference(s)