Gt(ROSA)26Sor^tm1(DTA)Riet
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(DTA)Riet
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Dieter Riethmacher
• MGI ID: MGI:3055489
• Synonyms: DTA, R26:lacZbpAfloxDTA, R26lacZbpA^floxDTA, R26:LacZ/DT-A, R26R-DTA, ROSA26-DT-A, ROSA26-DTA, ROSA-DTA
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(DTA)Riet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92789
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a splice acceptor sequence, a floxed lacZ, a diphtheria toxin fragment A (DTA) cassette, and a PGK-neo into intron 1. Staining demonstrated lacZ expression throughout embryogenesis and in every adult tissue examined. (J:92789)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:92789 Brockschnieder D, et al., Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination. Mol Cell Biol. 2004 Sep;24(17):7636-42
• All: 37 reference(s)