Cldn11^tm1Sts
Targeted Allele Detail

Summary

• Symbol: Cldn11^tm1Sts
• Name: claudin 11; targeted mutation 1, Shoichiro Tsukita
• MGI ID: MGI:3055494
• Synonyms: Cld11^-
• Gene: Cldn11 Location: Chr3:31204069-31218473 bp, + strand Genetic Position: Chr3, 15.14 cM
• Alliance: Cldn11^tm1Sts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92955
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance gene. RT-PCR of testes from mutant mice indicated no transcript was present. (J:92955)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn11 Mutation: 15 strains or lines available

References

• Original: J:92955 Kitajiri S, et al., Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential. J Cell Sci. 2004 Oct 1;117(Pt 21):5087-96
• All: 5 reference(s)