Hmx3/Hmx2^tm3Tlu
Targeted Allele Detail

Summary

• Symbol: Hmx3/Hmx2^tm3Tlu
• Name: H6 homeobox 3; targeted mutation 3, Thomas Lufkin
• MGI ID: MGI:3055500
• Synonyms: Hmx2^-;Hmx3^-
• Gene: Hmx3 Location: Chr7:131144596-131146654 bp, + strand Genetic Position: Chr7, 74.32 cM
• Alliance: Hmx3/Hmx2^tm3Tlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92940
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting vector was designed to replace an 11kb genomic fragment encompassing the Hmx2 and Hmx3 homeoboxes with a neomycin resistance gene. The only potential protein to be translated would be a truncated Hmx3 protein lacking the C-terminal portion essential for DNA-binding. (J:92940)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmx3 Mutation: 17 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or D3 (129S2/SvPas).

References

• Original: J:92940 Wang W, et al., Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Dev Cell. 2004 Sep;7(3):439-53
• All: 1 reference(s)