Hmx2^tm2Tlu
Targeted Allele Detail

Summary

• Symbol: Hmx2^tm2Tlu
• Name: H6 homeobox 2; targeted mutation 2, Thomas Lufkin
• MGI ID: MGI:3055505
• Synonyms: Hmx2^lacZ
• Gene: Hmx2 Location: Chr7:131150502-131159743 bp, + strand Genetic Position: Chr7, 74.34 cM
• Alliance: Hmx2^tm2Tlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92940
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES lacZ neo cassette was inserted into the coding region via homologous recombination. LacZ expression is under the control of the endogenous promoter (J:92940)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmx2 Mutation: 15 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or D3 (129S2/SvPas).

References

• Original: J:92940 Wang W, et al., Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Dev Cell. 2004 Sep;7(3):439-53
• All: 1 reference(s)