Sstr1^tm1Dric
Targeted Allele Detail

Summary

• Symbol: Sstr1^tm1Dric
• Name: somatostatin receptor 1; targeted mutation 1, Dietmar Richter
• MGI ID: MGI:3055541
• Synonyms: sst1-KO, Sstr1^-
• Gene: Sstr1 Location: Chr12:58258558-58260673 bp, + strand Genetic Position: Chr12, 25.61 cM
• Alliance: Sstr1^tm1Dric page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93009
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was replaced with a neomycin resistance gene. RT-PCR and Northern blot confirmed absence of transcript in mutant brains. (J:93009)

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sstr1 Mutation: 22 strains or lines available

References

• Original: J:93009 Kreienkamp HJ, et al., Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs. FEBS Lett. 1999 Dec 3;462(3):464-6
• All: 18 reference(s)