Gng3^tm1.1Rbs
Targeted Allele Detail

Summary

• Symbol: Gng3^tm1.1Rbs
• Name: guanine nucleotide binding protein (G protein), gamma 3; targeted mutation 1.1, Janet D Robishaw
• MGI ID: MGI:3055576
• Gene: Gng3 Location: Chr19:8814297-8816558 bp, - strand Genetic Position: Chr19, 5.76 cM
• Alliance: Gng3^tm1.1Rbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92791
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The complete coding region was replaced with a loxP site following Cre-mediated excision of a floxed sequence including a neo and the endogenous coding sequence. RT-PCR and Western blot confirmed that the gene was abolished by demonstrating lack of transcript and protein, respectively. (J:92791)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gng3 Mutation: 17 strains or lines available

References

• Original: J:92791 Schwindinger WF, et al., Mice with deficiency of G protein gamma3 are lean and have seizures. Mol Cell Biol. 2004 Sep;24(17):7758-68
• All: 4 reference(s)