Brca2^tm1Mhun
Targeted Allele Detail

Summary

• Symbol: Brca2^tm1Mhun
• Name: breast cancer 2, early onset; targeted mutation 1, MC Hung
• MGI ID: MGI:3055613
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm1Mhun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89083
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2kb 3' region of exon 11 was replaced with a neomycin resistance gene. Targeting was confirmed by Southern blot analysis. (J:89083)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca2^tm1Mhun

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:89083 Yan DH, et al., A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene. 2004 Mar 11;23(10):1896-901
• All: 1 reference(s)