Tg(Tal1-cre/ERT)1Jrg
Transgene Detail

Summary

• Symbol: Tg(Tal1-cre/ERT)1Jrg
• Name: transgene insertion 1, Joachim R Gothert
• MGI ID: MGI:3055721
• Synonyms: end-SCL-Cre-ER^T, SCL-Cre-ER^T
• Transgene: Tg(Tal1-cre/ERT)1Jrg Location: unknown
• Alliance: Tg(Tal1-cre/ERT)1Jrg page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Tal1-cre/ERT)1Jrg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tal1

• Mutation details: The transgene is composed of the 5' Tal1 enhancer element (from -7 to -0.9 kb relative to the transcription start site in exon 1a), the SV40 minimal promoter, and the Cre-ER^T cassette, including a rabbit Beta-globin intron. The enhancer element drove the endothelial-specific expression of the transgene. Cre was active in the presence of tamoxifen. (J:92965)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tal1 (species not specified) Summary of all recombinase alleles driven by Tal1. Comparative matrix view of recombinase activities

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Jam3^tm1.1Chav/Jam3^tm1.1Chav Tg(Tal1-cre/ERT)1Jrg/?	involves: 129 * C57BL/6
cn2  Disease Model	Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Tal1-cre/ERT)1Jrg/0	involves: 129 * C57BL/6
cn3	Eng^tm2.1Hma/Eng^tm2.1Hma Tg(Tal1-cre/ERT)1Jrg/0	involves: 129P2/OlaHsd * C57BL/6
cn4	Tg(Tal1-cre/ERT)1Jrg/0 Tsc1^tm1Djk/Tsc1^tm1Djk	involves: 129S4/SvJae * C57BL/6

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4
show or hide all annotated terms
cardiovascular system		√	√	√
abnormal retina vasculature morphology				√
increased angiogenesis				√
arteriovenous malformation		√	√
gastrointestinal arteriovenous malformation		√
large intestine hemorrhage		√
abnormal vascular wound healing		√	√
digestive/alimentary system		√
gastrointestinal arteriovenous malformation		√
large intestine hemorrhage		√
homeostasis/metabolism		√	√	√
abnormal vascular wound healing		√	√
edema				√
liver/biliary system				√
increased liver tumor incidence				√
mortality/aging		√
moribund		√
neoplasm	√			√
increased liver tumor incidence				√
decreased metastatic potential	√
increased metastatic potential				√
increased hemangiosarcoma incidence				√
increased extremity angiosarcoma incidence				√
vision/eye				√
abnormal retina morphology				√
abnormal retina vasculature morphology				√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn2
hereditary hemorrhagic telangiectasia IDs hereditary hemorrhagic telangiectasia       DOID:1270 ICD10CM:I78.0 ICD9CM:448.0 MESH:D013683 NCI:C35064 OMIM:187300 OMIM:600376 OMIM:615506 ORDO:774 UMLS_CUI:C0039445 Close	√

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tal1-cre/ERT)1Jrg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92965 Gothert JR, et al., Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood. 2004 Sep 15;104(6):1769-77
• All: 46 reference(s)