Tg(Tal1-cre/ERT)1Jrg
Transgene Detail

Summary

• Symbol: Tg(Tal1-cre/ERT)1Jrg
• Name: transgene insertion 1, Joachim R Gothert
• MGI ID: MGI:3055721
• Synonyms: end-SCL-Cre-ER^T, SCL-Cre-ER^T
• Transgene: Tg(Tal1-cre/ERT)1Jrg Location: unknown
• Alliance: Tg(Tal1-cre/ERT)1Jrg page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Tal1-cre/ERT)1Jrg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tal1

• Mutation details: The transgene is composed of the 5' Tal1 enhancer element (from -7 to -0.9 kb relative to the transcription start site in exon 1a), the SV40 minimal promoter, and the Cre-ER^T cassette, including a rabbit Beta-globin intron. The enhancer element drove the endothelial-specific expression of the transgene. Cre was active in the presence of tamoxifen. (J:92965)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tal1 (species not specified) Summary of all recombinase alleles driven by Tal1. Comparative matrix view of recombinase activities

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tal1-cre/ERT)1Jrg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92965 Gothert JR, et al., Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood. 2004 Sep 15;104(6):1769-77
• All: 45 reference(s)