Poli^d
Spontaneous Allele Detail

Summary

• Symbol: Poli^d
• Name: polymerase (DNA directed), iota; polymerase iota deficient
• MGI ID: MGI:3055735
• Synonyms: Poli^-, Poli¹²⁹
• Gene: Poli Location: Chr18:70641751-70663691 bp, - strand Genetic Position: Chr18, 44.48 cM, cytoband E2
• Alliance: Poli^d page

Mutation origin

• Strain of Origin: 129

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A C-to-A nonsense mutation changes codon 27 from serine (TCG) to an amber stop codon (TAG) (SW:Q6R3M4 p.S27*), and results in a truncated protein lacking any catalytic function. The allele was present in every 129 strain analyzed, including 129P3/J, 129X1/SvJ, 129P1/ReJ and 129P2/Ola. C57BL/6J and BALB/c mice did not contain the mutation. (J:85061, J:228234, J:273998)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Poli Mutation: 45 strains or lines available

References

• Original: J:85061 McDonald JP, et al., 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. J Exp Med. 2003 Aug 18;198(4):635-43
• All: 11 reference(s)