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Btrctm1Paga
Targeted Allele Detail
Summary
Symbol: Btrctm1Paga
Name: beta-transducin repeat containing protein; targeted mutation 1, Michele Pagano
MGI ID: MGI:3055737
Synonyms: BetaTrcp1-
Gene: Btrc  Location: Chr19:45352173-45518452 bp, + strand  Genetic Position: Chr19, 38.75 cM, cytoband D1
Alliance: Btrctm1Paga page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93010
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting event deleted a large segment of exon 5 that encodes amino acids 154-212 of the protein, including all but four amino acids comprising the F box and 22 downstream amino acids. The neomycin resistance gene is inserted in reverse orientation, and stop codons occur in all three reading frames within exon 5 following codon 153. The splice acceptor site of exon 5 is intact, and exons 6 and 7 are both out of frame with exon 4. No expression was detected in homozygous mutant mouse embryonic fibroblasts or other tissues examined by Northern blot analysis or by immunoprecipitation followed by immunoblot analysis. (J:93010)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Btrc Mutation:  46 strains or lines available
References
Original:  J:93010 Guardavaccaro D, et al., Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev Cell. 2003 Jun;4(6):799-812
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory