rda
Spontaneous Allele Detail

Summary

• Symbol: rda
• Name: roundabout
• MGI ID: MGI:3055794
• Synonyms: vertigo, vto
• Gene: rda Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: rda page

Cochlear hair cell abnormalities in rda/rda and Elmod1^rda-2J/Elmod1^rda-2J mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Spontaneous (Null/knockout) Mutation: Intergenic deletion rda involves 2 genes/genome features (Elmod1, Tnfaip8l3) View all Mutation details: A spontaneous deletion removed 138 kb, including exons 1-5 of Elmod1 and Tnfaip8l3. Western blot analysis confirmed the absence of protein expression in the brain. (J:187273) Inheritance: Recessive

Molecular structure of the rda mutation

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any rda Mutation: 1 strain or line available

References

• Original: J:187273 Johnson KR, et al., Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia. PLoS One. 2012;7(4):e36074
• All: 2 reference(s)