Fosl1tm2.1Wag
Targeted Allele Detail
|
Symbol: |
Fosl1tm2.1Wag |
Name: |
fos-like antigen 1; targeted mutation 2.1, Erwin F Wagner |
MGI ID: |
MGI:3055993 |
Synonyms: |
fra-1- |
Gene: |
Fosl1 Location: Chr19:5497726-5505966 bp, + strand Genetic Position: Chr19, 4.33 cM
|
Alliance: |
Fosl1tm2.1Wag page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:93053
|
Parent Cell Line: |
HM-1 (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd-Hprt1b-m3
|
|
Allele Type: |
|
Targeted (Null/knockout, Reporter) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: Crossing Fosl1tm2Wag with mice expressing Cre in the embryo proper created this allele in which the floxed region containing exons 3 and 4 (containing the dimerization and the DNA-binding domains) was excised. Upon excision, the 3' GFP was spliced to the N-terminal part of the transcript and was thereby activated. Western blot detected the fusion protein using an anti-GFP antibody. Immunofluorescence confirmed GFP activation.
(J:93053)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Fosl1 Mutation: |
16 strains or lines available
|
|
Original: |
J:93053 Eferl R, et al., The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J. 2004 Jul 21;23(14):2789-99 |
All: |
5 reference(s) |
|