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Fosl1tm2.1Wag
Targeted Allele Detail
Summary
Symbol: Fosl1tm2.1Wag
Name: fos-like antigen 1; targeted mutation 2.1, Erwin F Wagner
MGI ID: MGI:3055993
Synonyms: fra-1-
Gene: Fosl1  Location: Chr19:5497726-5505966 bp, + strand  Genetic Position: Chr19, 4.33 cM
Alliance: Fosl1tm2.1Wag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93053
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCrossing Fosl1tm2Wag with mice expressing Cre in the embryo proper created this allele in which the floxed region containing exons 3 and 4 (containing the dimerization and the DNA-binding domains) was excised. Upon excision, the 3' GFP was spliced to the N-terminal part of the transcript and was thereby activated. Western blot detected the fusion protein using an anti-GFP antibody. Immunofluorescence confirmed GFP activation. (J:93053)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fosl1 Mutation:  16 strains or lines available
References
Original:  J:93053 Eferl R, et al., The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J. 2004 Jul 21;23(14):2789-99
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory