Enah^tm1Fbg
Targeted Allele Detail

Summary

• Symbol: Enah^tm1Fbg
• Name: ENAH actin regulator; targeted mutation 1, Frank B Gertler
• MGI ID: MGI:3056050
• Synonyms: Mena^Betageo
• Gene: Enah Location: Chr1:181723949-181847555 bp, - strand Genetic Position: Chr1, 84.93 cM
• Alliance: Enah^tm1Fbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53259
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The replacement of exons 2 and 4 with a beta-geo cassette left the beta-geo under the control of the initiator methionine. Western blot showed complete lack of endogenous protein in mutant brains. Beta-galactosidase expression was demonstrated in the developing and adult brains of mutants. (J:53259)

Expression

In Mice Carrying this Mutation:	57 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Enah Mutation: 208 strains or lines available

References

• Original: J:53259 Lanier LM, et al., Mena is required for neurulation and commissure formation. Neuron. 1999 Feb;22(2):313-25
• All: 10 reference(s)