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Hdac5tm1Eno
Targeted Allele Detail
Summary
Symbol: Hdac5tm1Eno
Name: histone deacetylase 5; targeted mutation 1, Eric N Olson
MGI ID: MGI:3056065
Synonyms: Hdac5-, HdaclacZ
Gene: Hdac5  Location: Chr11:102085244-102120968 bp, - strand  Genetic Position: Chr11, 65.82 cM
Alliance: Hdac5tm1Eno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93021
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 3-7 with a lacZ-neo cassette. The deleted sequence encoded residues 32-298, including the region responsible for interaction with MEF2. RT-PCR and sequencing revealed that exon 2 was spliced to the 5' end of exon 3, which was spliced to the lacZ coding sequence. Transcripts of the wild-type were not found in hearts from mutants. Staining indicated that lacZ expression reflected that of the endogenous gene during pre- and postnatal development. (J:93021)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac5 Mutation:  57 strains or lines available
References
Original:  J:93021 Chang S, et al., Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol. 2004 Oct;24(19):8467-76
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory