Hdac5tm1Eno
Targeted Allele Detail
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Symbol: |
Hdac5tm1Eno |
Name: |
histone deacetylase 5; targeted mutation 1, Eric N Olson |
MGI ID: |
MGI:3056065 |
Synonyms: |
Hdac5-, HdaclacZ |
Gene: |
Hdac5 Location: Chr11:102085244-102120968 bp, - strand Genetic Position: Chr11, 65.82 cM
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Alliance: |
Hdac5tm1Eno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:93021
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting vector was designed to replace exons 3-7 with a lacZ-neo cassette. The deleted sequence encoded residues 32-298, including the region responsible for interaction with MEF2. RT-PCR and sequencing revealed that exon 2 was spliced to the 5' end of exon 3, which was spliced to the lacZ coding sequence. Transcripts of the wild-type were not found in hearts from mutants. Staining indicated that lacZ expression reflected that of the endogenous gene during pre- and postnatal development.
(J:93021)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hdac5 Mutation: |
57 strains or lines available
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Original: |
J:93021 Chang S, et al., Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol. 2004 Oct;24(19):8467-76 |
All: |
28 reference(s) |
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