Hoxa1^tm1Rez
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm1Rez
• Name: homeobox A1; targeted mutation1 1, Rene Rezsohazy
• MGI ID: MGI:3056069
• Synonyms: Hoxa1^WM-AA
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm1Rez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93020
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed replace the WM residues with AA residues in the hexapeptide sequence of the endogenous locus. Crossing with ubiquitously expressing Cre mice excised a floxed neo that was also introduced by the vector. Neither the expression level nor the stability of the protein was altered. (J:93020)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:93020 Remacle S, et al., Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. Mol Cell Biol. 2004 Oct;24(19):8567-75
• All: 2 reference(s)