Sox15^tm1Imad
Targeted Allele Detail

Summary

• Symbol: Sox15^tm1Imad
• Name: SRY (sex determining region Y)-box 15; targeted mutation 1, Ibrahim M Adham
• MGI ID: MGI:3056078
• Synonyms: Sox15^-
• Gene: Sox15 Location: Chr11:69546140-69547553 bp, + strand Genetic Position: Chr11, Syntenic
• Alliance: Sox15^tm1Imad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93031
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a 2.5-kb fragment containing the 5' flanking region and part of exon 1, including sequence encoding the HMG domain. Northern and Western blot analyses confirmed inactivation of the gene. (J:93031)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox15 Mutation: 14 strains or lines available

References

• Original: J:93031 Lee HJ, et al., Sox15 is required for skeletal muscle regeneration. Mol Cell Biol. 2004 Oct;24(19):8428-36
• All: 2 reference(s)