Vamp8^tm1Hong
Targeted Allele Detail

Summary

• Symbol: Vamp8^tm1Hong
• Name: vesicle-associated membrane protein 8; targeted mutation 1, Wanjin Hong
• MGI ID: MGI:3056083
• Synonyms: Vamp8^-
• Gene: Vamp8 Location: Chr6:72362204-72367650 bp, - strand Genetic Position: Chr6, 32.27 cM
• Alliance: Vamp8^tm1Hong page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93035
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, corresponding to amino acids 2-52, was replaced with an IRES-lacZ and floxed PGK-neo cassette. Western blot showed lack of protein in mutants. (J:93035)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vamp8 Mutation: 19 strains or lines available

References

• Original: J:93035 Wang CC, et al., A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells. Dev Cell. 2004 Sep;7(3):359-71
• All: 22 reference(s)