Ctnnb1^tm1Yy
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^tm1Yy
• Name: catenin beta 1; targeted mutation 1, Yingzi Yang
• MGI ID: MGI:3056113
• Synonyms: Catnb^c, Catnby^c
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^tm1Yy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93028
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo was inserted into intron 6, as well as two loxP sites placed in intron 2 and downstream of the neo. Crossing with mice expressing FLP in the germline excised the neo, leaving exons 3 through 6 floxed. (J:93028)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:93028 Guo X, et al., Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev. 2004 Oct 1;18(19):2404-17
• All: 7 reference(s)