Etv6^tm2Sho
Targeted Allele Detail

Summary

• Symbol: Etv6^tm2Sho
• Name: ets variant 6; targeted mutation 2, Stuart H Orkin
• MGI ID: MGI:3056142
• Synonyms: Floxed-neo+
• Gene: Etv6 Location: Chr6:134012663-134247121 bp, + strand Genetic Position: Chr6, 64.58 cM, cytoband G2
• Alliance: Etv6^tm2Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93052
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank exon 7, which encodes the DNA binding domain. (J:93052)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etv6 Mutation: 144 strains or lines available

References

• Original: J:93052 Hock H, et al., Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 2004 Oct 1;18(19):2336-41
• All: 2 reference(s)