Tg(AlbLCAT)1Jdm
Transgene Detail

Summary

• Symbol: Tg(AlbLCAT)1Jdm
• Name: transgene insertion 1, John D McNeish
• MGI ID: MGI:3056401
• Synonyms: HuLCAT, HuLCATTg, HuLCATTgl 1,
• Transgene: Tg(AlbLCAT)1Jdm Location: unknown
• Alliance: Tg(AlbLCAT)1Jdm page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(AlbLCAT)1Jdm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LCAT (3931)

  Lcat	(MGI:96755)

• Mutation details: The transgene contains the murine albumin promoter and enhancer sequences, and the entire human lecithin-cholesterol acyltransferase (LCAT) gene with 550 bp of 3' untranslated region. Plasma LCAT activities in transgenic mice are increased by 2.6- to 10.8-fold over the non-transgenic controls. (J:93245)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:121992 Francone OL, et al., Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism. J Clin Invest. 1995 Sep;96(3):1440-8
• All: 5 reference(s)