Ago2^tm1Ghan
Targeted Allele Detail

Summary

• Symbol: Ago2^tm1Ghan
• Name: argonaute RISC catalytic subunit 2; targeted mutation 1, Greggory J Hannon
• MGI ID: MGI:3056454
• Synonyms: Ago2^-
• Gene: Ago2 Location: Chr15:72967693-73056777 bp, - strand Genetic Position: Chr15, 33.92 cM
• Alliance: Ago2^tm1Ghan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93081
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Duplication, Insertion
• Ago2^tm1Ghan involves 1 genes/genome features (Ago2) View all
• Mutation details: A targeting vector was designed to insert a PGK-neo and a duplicate of exons 3-6 into the endogenous locus. No mRNA was detected by RT-PCR. (J:93081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ago2 Mutation: 56 strains or lines available

References

• Original: J:93081 Liu J, et al., Argonaute2 is the catalytic engine of mammalian RNAi. Science. 2004 Sep 3;305(5689):1437-41
• All: 3 reference(s)