Dll4^tm1Grid
Targeted Allele Detail

Summary

• Symbol: Dll4^tm1Grid
• Name: delta like canonical Notch ligand 4; targeted mutation 1, Tom Gridley
• MGI ID: MGI:3056460
• Gene: Dll4 Location: Chr2:119156286-119166145 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E3
• Alliance: Dll4^tm1Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93125
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and all of exons 2-6 were replaced with a PGK-neo cassette via homologous recombination. (J:93125)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll4 Mutation: 27 strains or lines available

References

• Original: J:93125 Krebs LT, et al., Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 2004 Oct 15;18(20):2469-73
• All: 2 reference(s)