Slc1a3^tm1Wst
Targeted Allele Detail

Summary

• Symbol: Slc1a3^tm1Wst
• Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3; targeted mutation 1, Wilhelm Stoffel
• MGI ID: MGI:3056511
• Synonyms: glast1^-
• Gene: Slc1a3 Location: Chr15:8663608-8740248 bp, - strand Genetic Position: Chr15, 3.82 cM, cytoband A2
• Alliance: Slc1a3^tm1Wst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93201
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exon 2 was replaced with a neomycin resistance cassette. Northern blot and Western blot analysis showed that transcripts from mutants lacked exon 2 and that protein was not detected in brains. (J:93201)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc1a3 Mutation: 70 strains or lines available

References

• Original: J:93201 Stoffel W, et al., Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice. Brain Res Mol Brain Res. 2004 Sep 28;128(2):170-81
• All: 2 reference(s)