Nmu^tm1Mko
Targeted Allele Detail

Summary

• Symbol: Nmu^tm1Mko
• Name: neuromedin U; targeted mutation 1, Masayasu Kojima
• MGI ID: MGI:3056512
• Synonyms: NMKO, Nmu^-
• Gene: Nmu Location: Chr5:76481342-76511624 bp, - strand Genetic Position: Chr5, 40.93 cM
• Alliance: Nmu^tm1Mko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93213
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: PGK-Neo replaced exon 9 (the active C-terminal portion of Nmu) via homologous recombination. Immunohistochemistry confirms the absence of protein. (J:93213)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nmu Mutation: 19 strains or lines available

References

• Original: J:93213 Hanada R, et al., Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med. 2004 Oct;10(10):1067-73
• All: 15 reference(s)