Lats2^tm1Raz
Targeted Allele Detail

Summary

• Symbol: Lats2^tm1Raz
• Name: large tumor suppressor 2; targeted mutation 1, Razqallah Hakem
• MGI ID: MGI:3056530
• Gene: Lats2 Location: Chr14:57927119-57983669 bp, - strand Genetic Position: Chr14, 30.28 cM
• Alliance: Lats2^tm1Raz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93191
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Serine 371 was replaced with an in-frame stop codon followed by an inverted neomycin cassette via homologous recombination, disrupting translation of the carboxy-terminal kinase domain. Western and Northern analysis confirms absence of full-length or a shorter Lats2 peptide and presence of a longer mRNA. (J:93191)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lats2 Mutation: 44 strains or lines available

References

• Original: J:93191 McPherson JP, et al., Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 2004 Sep 15;23(18):3677-88
• All: 1 reference(s)