Krt10^tm2Tmm
Targeted Allele Detail

Summary

• Symbol: Krt10^tm2Tmm
• Name: keratin 10; targeted mutation 2, Thomas M Magin
• MGI ID: MGI:3056582
• Synonyms: K10^-
• Gene: Krt10 Location: Chr11:99276080-99280190 bp, - strand Genetic Position: Chr11, 62.92 cM
• Alliance: Krt10^tm2Tmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93249
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-HPRT minigene replaced 414 bp of the promoter region and exons 1 and 2. Immunofluorescence, Northern blot and Western blot analyses confirmed absence of the protein in all epidermal strata of mutant mice. (J:93249)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Krt10 Mutation: 32 strains or lines available

References

• Original: J:93249 Reichelt J, et al., Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice. Mol Biol Cell. 2001 Jul;12(6):1557-68
• All: 7 reference(s)