Gmfb^tm1Lim
Targeted Allele Detail

Summary

• Symbol: Gmfb^tm1Lim
• Name: glia maturation factor, beta; targeted mutation 1, Ramon Lim
• MGI ID: MGI:3056591
• Synonyms: Gmf^-, GMF-KO
• Gene: Gmfb Location: Chr14:47045606-47059699 bp, - strand Genetic Position: Chr14, 24.32 cM
• Alliance: Gmfb^tm1Lim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93177
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 2-6. Western blot of mutant brain and spinal cord showed lack of protein. (J:93177)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gmfb Mutation: 17 strains or lines available

References

• Original: J:93177 Zaheer A, et al., Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes. Neurochem Res. 2004 Sep;29(8):1473-80
• All: 9 reference(s)