Ctnnd2^tm1Lxin
Targeted Allele Detail

Summary

• Symbol: Ctnnd2^tm1Lxin
• Name: catenin delta 2; targeted mutation 1, Xin Liu
• MGI ID: MGI:3056606
• Synonyms: delta-cat^-
• Gene: Ctnnd2 Location: Chr15:30172739-31029487 bp, + strand Genetic Position: Chr15, 12.02 cM
• Alliance: Ctnnd2^tm1Lxin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93226
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: GFP followed by a stop codon and a PGK-hygro cassette were inserted within exon 9, preventing transcription of the carboxyl terminal region. Northern, western and immunohistochemical analysis confirmed a truncated RNA and the absence of protein in the brain. (J:93226)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctnnd2 Mutation: 65 strains or lines available

References

• Original: J:93226 Israely I, et al., Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction. Curr Biol. 2004 Sep 21;14(18):1657-63
• All: 11 reference(s)