Cabp4^tm1Kpal
Targeted Allele Detail

Summary

• Symbol: Cabp4^tm1Kpal
• Name: calcium binding protein 4; targeted mutation 1, Krzysztof Palczewski
• MGI ID: MGI:3056615
• Gene: Cabp4 Location: Chr19:4185422-4189608 bp, - strand Genetic Position: Chr19, 3.84 cM
• Alliance: Cabp4^tm1Kpal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93216
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and part of exon 2 were replaced with a PGK-neo cassette via homologous recombination. Western and immunohistochemical analysis confirmed the absence of protein in retinas. (J:93216)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cabp4 Mutation: 12 strains or lines available

References

• Original: J:93216 Haeseleer F, et al., Essential role of Ca(2+)-binding protein 4, a Ca(v)1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci. 2004 Oct;7(10):1079-87
• All: 4 reference(s)