Tg(H2KmPCC)2939Stoe
Transgene Detail

Summary

• Symbol: Tg(H2KmPCC)2939Stoe
• Name: transgene insertion 2939, Stephan Oehen
• MGI ID: MGI:3056682
• Synonyms: mPCC
• Transgene: Tg(H2KmPCC)2939Stoe Location: unknown
• Alliance: Tg(H2KmPCC)2939Stoe page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2KmPCC)2939Stoe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  pigeon	PCC

• Mutation details: Pigeon cytochrome c was engineered for expression in lymphoid tissues of transgenic mice in two forms. The form of cytochrome c in this construct is expressed as a type II plasma membrane protein (mPCC) by replacing the NH2-terminal mitochondrial targeting sequence with the influenza neuraminidase type II signal anchor. mRNA expression levels are higher in mice carrying this transgene than in mice carrying Tg(H2KePCC)2403. PCC was expressed in thymus, spleen and LPS stimulated B cells as determined by Northern blot. (J:92997)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92997 Oehen S, et al., Antigen compartmentation and T helper cell tolerance induction. J Exp Med. 1996 Jun 1;183(6):2617-26
• All: 9 reference(s)