Tg(Tcrb)93Vbo
Transgene Detail

Summary

• Symbol: Tg(Tcrb)93Vbo
• Name: transgene insertion 93, Harald von Boehmer
• MGI ID: MGI:3056727
• Synonyms: HYbeta, TCRBbeta8.2, TCRB TG, Vbeta8.2^tg
• Transgene: Tg(Tcrb)93Vbo Location: unknown
• Alliance: Tg(Tcrb)93Vbo page

Transgene origin

• Strain of Origin: (CBA/BrA x C57BL/LiA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcrb)93Vbo expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcrb (MGI:98578)

• Mutation details: The transgene contains a rearranged genomic segment derived from the Tcrb locus, and was constructed from B6 (Tcrb-V8.2,Tcrb-D) and BALB/c (Tcrb-J, Tcrb-C) sequences. Over 98% of T cells express the transgenic TCR-beta chain in hemizygous mice. The rearranged beta-chain sequence was isolated from an anti-H-Y, H-2D^b-restricted CD8⁺ T cell clone, B6.2.16. (J:51117, J:93247)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

In transgenic mice, T lymphocytes express the transgene on cell surfaces while the protein products encoded by endogenous Tcrb genes are not expressed. Most homozygous transgenic mice do not survive beyond postnatal week four.

References

• Original: J:93247 Uematsu Y, et al., In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell. 1988 Apr 25;52(6):831-41
• All: 28 reference(s)