Tg(Cd8aCd8b)3Erob
Transgene Detail

Summary

• Symbol: Tg(Cd8aCd8b)3Erob
• Name: transgene insertion 3, Ellen Robey
• MGI ID: MGI:3056809
• Transgene: Tg(Cd8aCd8b)3Erob Location: unknown
• Alliance: Tg(Cd8aCd8b)3Erob page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cd8aCd8b)3Erob expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Cd8a (24930)

  Cd8a	(MGI:88346)

• Mutation details: The murine Cd8a and Cd8b1 coding sequences were placed under the control of the T cell-specific CD2 promoter. Six copies of the transgene incorporated into the genome. The resulting heterodimer complex expressed was the "CD8.1" variant that differs from the "CD8.2" variant complex normally expressed in C57BL/6 mice. Transgenic expression was detected on almost all thymocytes and T cells as determined by flow cytometry using antibodies that can distinguish the two CD8 variants. (J:93004)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:93004 Robey EA, et al., Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell. 1991 Jan 11;64(1):99-107
• All: 6 reference(s)