Tg(DBH-Gal)1923Stei
Transgene Detail

Summary

• Symbol: Tg(DBH-Gal)1923Stei
• Name: transgene insertion 1923, Robert A Steiner
• MGI ID: MGI:3057122
• Synonyms: GALANIN-Tg, GalOE, GalOE/D, GALTG
• Transgene: Tg(DBH-Gal)1923Stei Location: unknown
• Alliance: Tg(DBH-Gal)1923Stei page

Transgene origin

• Strain of Origin: (SJL x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(DBH-Gal)1923Stei expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gal (MGI:95637)

• Mutation details: The transgene contains a 5.8 Kb sequence of human dopamine beta-hydroxylase promoter and a 4.6 Kb sequence of the mouse galanin gene. In situ hybridization analysis of brain detects a 5-fold increase in galanin mRNA levels in the locus coeruleus region. Radioimmunoassay reveals a 2-fold increase in gene product peptide level in the forebrain. An increase of galanin-like immunoreactive staining and fiber density is also detected. (J:77625)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:77625 Mazarati AM, et al., Modulation of hippocampal excitability and seizures by galanin. J Neurosci. 2000 Aug 15;20(16):6276-81
• All: 14 reference(s)