Tg(PDGFB-APP)5Lms
Transgene Detail
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Symbol: |
Tg(PDGFB-APP)5Lms |
Name: |
transgene insertion 5, Lennart Mucke |
MGI ID: |
MGI:3057135 |
Synonyms: |
hAPPWT, I5, line I5, PDGF-APPWT |
Transgene: |
Tg(PDGFB-APP)5Lms Location: unknown
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Alliance: |
Tg(PDGFB-APP)5Lms page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(PDGFB-APP)5Lms expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
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Mutation details: The transgene contains the reverted wild-type human amyloid protein precursor, APP, under the control of the human platelet derived growth factor, B polypeptide, (PDGFB) promoter. Hemizygous transgenic mice express immunodetectable transgene product in cerebral neurons, with the highest level of expression occurring in the neocortex and hippocampus. ELISA analysis of neocortical and hippocampal tissue revealed approximate total amyloid beta peptides levels and 42 amino acid length amyloid beta peptides levels that were lower than levels found in mice carrying the mutant human amyloid protein precursor transgene Tg(PDGFB-APPSwInd)20Lms.
(J:62290)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:62290 Mucke L, et al., High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000 Jun 1;20(11):4050-8 |
All: |
19 reference(s) |
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