Cdh18^{Tg(GFAP-APOE_i4)1Hol}
Transgenic Allele Detail

Summary

• Symbol: Cdh18^{Tg(GFAP-APOE_i4)1Hol}
• Name: cadherin 18; transgene insertion 1, David M Holtzman
• MGI ID: MGI:3057182
• Synonyms: GFAP-apoE4 line1, Tg(GFAP-APOE*4)1Hol, Tg(GFAP-APOE4)1Hol
• Gene: Cdh18 Location: Chr15:22549108-23474504 bp, + strand Genetic Position: Chr15, 8.54 cM
• Alliance: Cdh18^{Tg(GFAP-APOE_i4)1Hol} page

Transgene origin

• Strain of Origin: C57BL/6 or CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Cdh18^{Tg(GFAP-APOE_i4)1Hol} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: The transgene contains sequence encoding human apolipoprotein E4 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Five lines were created (lines 1, 3, 11, 19 and 22) with line 1 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. Line 1 inserted into coordinates 23364633-23373281 (Build GRCm38/mm10) resulting in an 8648 bp deletion. Founder line 1 has a copy number of 10-15. (J:93487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh18 Mutation: 56 strains or lines available

References

• Original: J:93487 Sun Y, et al., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72
• All: 9 reference(s)