Dppa3^tm1Dcp
Targeted Allele Detail

Summary

• Symbol: Dppa3^tm1Dcp
• Name: developmental pluripotency-associated 3; targeted mutation 1, David C Page
• MGI ID: MGI:3057184
• Synonyms: Dppa3^-, Dppa3^tm1WHT
• Gene: Dppa3 Location: Chr6:122603383-122607230 bp, + strand Genetic Position: Chr6, 57.72 cM
• Alliance: Dppa3^tm1Dcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93295
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced by a floxed hygromycin-thymidine kinase cassette. Transient cre expression in ES cells excised the cassette, leaving a single loxp site and the non-coding portion of the gene. RT-PCR of mutant ovaries demonstrated a lack of transcript. (J:93295)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dppa3 Mutation: 24 strains or lines available

References

• Original: J:93295 Bortvin A, et al., Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. BMC Dev Biol. 2004 Mar 23;4(1):2
• All: 1 reference(s)