Tg(GFAP-APOE_i3)37Hol
Transgene Detail

Summary

• Symbol: Tg(GFAP-APOE_i3)37Hol
• Name: transgene insertion 37, David M Holtzman
• MGI ID: MGI:3057188
• Synonyms: GFAP-apoE3 line 37, Tg(GFAP-APOE*3)37Hol, Tg(GFAP-APOE3)37Hol
• Transgene: Tg(GFAP-APOE_i3)37Hol Location: unknown
• Alliance: Tg(GFAP-APOE_i3)37Hol page

Transgene origin

• Strain of Origin: C57BL/6 and CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-APOE_i3)37Hol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: The transgene contains sequence encoding human apolipoprotein E3 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Two lines were created (lines 2 and 37) with line 37 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. (J:93487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:93487 Sun Y, et al., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72
• All: 17 reference(s)