Hsf4^tm1Anak
Targeted Allele Detail

Summary

• Symbol: Hsf4^tm1Anak
• Name: heat shock transcription factor 4; targeted mutation 1, Akira Nakai
• MGI ID: MGI:3057199
• Synonyms: Hsf4^-
• Gene: Hsf4 Location: Chr8:105996433-106002477 bp, + strand Genetic Position: Chr8, 53.04 cM, cytoband D1
• Alliance: Hsf4^tm1Anak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93301
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and exons 3-8 were replaced with a neo. The deleted sequence encode amino acids 68-248 and include part of the DNA-binding domain and an oligomerization domain. Western blot and In situ hybridization of lenses from mutant mice confirmed lack of expression. (J:93301)

Expression

In Mice Carrying this Mutation:	120 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hsf4 Mutation: 31 strains or lines available

References

• Original: J:93301 Fujimoto M, et al., HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004 Nov 27;23(21):4297-306
• All: 3 reference(s)