Tg(KITLG)3Ygy
Transgene Detail

Summary

• Symbol: Tg(KITLG)3Ygy
• Name: transgene insertion 3, Yong-guang Yang
• MGI ID: MGI:3057265
• Transgene: Tg(KITLG)3Ygy Location: unknown
• Alliance: Tg(KITLG)3Ygy page

Transgene origin

• Strain of Origin: NIH Swiss

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KITLG)3Ygy expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KITLG (4254)

  Kitl	(MGI:96974)

• Mutation details: The transgene construct contains porcine kit ligand (KITL) controlled by the human cytomegalovirus promoter. The Tg(IL3)1Ygy, Tg(CSF2)2Ygy and Tg(KITLG)3Ygy transgenic constructs were co-injected into NIH/Swiss oocytes in David Bodine's lab at NCI. (J:94302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

White blood cells from mice that carry this transgene in conjunction with Tg(IL3)1Ygy and Tg(CSF2)2Ygy and that are also homozygous for Prkdc^scid are CD4^-, CD8^-, CD3^-, IgM^-, CD19^- and Mac-1⁺ by flow cytometric (FMC) analysis.

References

• Original: J:94302 Yang YG, et al., Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation. 2000 Feb;7(1):58-64
• All: 6 reference(s)